For some time it was believed that the responsibility for body mass index (BMI) in humans take on only two loci (is the specific location of a gene or DNA sequence on a chromosome), a FTO (fat mass and obesity associated (protein coding)) and MC4R (function: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH; this receptor is mediated by G proteins that stimulate adenylate, cyclase). This fact has been generally accepted, till in the journal Nature Genetics (January 2009, Volume 41) has not been published studies in the article “Six new loci associated with body mass index highlight a neuronal influence on body weight regulation” which make a considerable adjustment in understanding the influence of central nervous system (CNS) on BMI.  Full article here: USScience.com